Characterizing the MCT-1:DenR Complex, a Translational Enhancer for Lymphoma Survival
نویسندگان
چکیده
منابع مشابه
MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles.
MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we established that MCT-1 protein interacts with the cap complex through its PUA domai...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.1212